LONDON (AP) 鈥 Jannik Sinner felt ill. He was dizzy. Hadn't slept well the night before. Wimbledon's top-seeded man, who recently attained the No. 1 ranking, definitely did not want to quit playing against Daniil Medvedev in the quarterfinals, but things were not looking good.

Sinner was treated by a trainer and left the court during the third set Tuesday, then briefly surged before faltering again down the stretch, eventually losing to a more-aggressive-than-usual Daniil Medvedev 6-7 (7), 6-4, 7-6 (4), 2-6, 6-3.

鈥淚 was struggling physically,鈥 said Sinner, who had won his past five matches against Medvedev, including a five-setter in in January. 鈥淚t was not an easy moment. I tried to fight with that what I had today.鈥

It wasn't enough.

Not against the crafty Medvedev, the 2021 U.S. Open champion who now will face in the semifinals at the All England Club for the second consecutive year.

鈥淲as a bit up-and-down match, in a way, from both sides,鈥 Medvedev said.

Alcaraz, the defending champion and No. 3 seed, took a bit of time to get going in his quarterfinal, but once he did, there was no stopping him during a 5-7, 6-4, 6-2, 6-2 victory over No. 12 Tommy Paul at No. 1 Court.

鈥淲e try just to find solutions,鈥 said Alcaraz, coming off a title at the French Open last month and seeking his fourth Grand Slam trophy. 鈥淔or me, obviously, it's going to be really difficult to play my best tennis every match.鈥

Over at Centre Court, it was not immediately clear what was wrong with Sinner, who leaned back in his sideline chair, rested his head in a hand and had his heart rate checked before heading to the locker room. During a later changeover, Sinner draped a towel over his head.

While he did regain his usual verve, particularly on his booming forehand, and pushed the match to a fifth set 鈥 the 36th this fortnight and the most at any Grand Slam tournament in the Open era, which dates to 1968 鈥 Sinner could not get over the line.

Even though he won more points (164-160), accumulated more winners (61-56), made fewer unforced errors (49-45), hit more aces (17-15) and finished with far fewer double-faults (11-4).

鈥淚t鈥檚 a tough one to swallow,鈥 Sinner said.

Medvedev, a 28-year-old from Russia, began playing closer to the baseline than he often does. He found the space to deliver more winners, compiling 13 in the closing set alone, broke for a 3-1 lead in the fifth, and was on his way back to the semifinals.

鈥淭oday,鈥 Medvedev said, 鈥渁 lot of tactical things worked well.鈥

After eliminating the 22-year-old Sinner, Medvedev now goes up against the 21-year-old Alcaraz, back-to-back tests against the two new young stars of men's tennis.

Against Paul, Alcaraz raised his level after a so-so opening set, putting together a 26-12 advantage in winners over the last three.

鈥淲hen he starts building energy and building momentum ... it feels a little bit different than most of the other guys,鈥 Paul said. 鈥淗e can play some seriously amazing, amazing tennis.鈥

In the women鈥檚 quarterfinals, for the first time in her 43rd Slam, defeating qualifier Lulu Sun 5-7, 6-4, 6-1, and French Open runner-up Jasmine Paolini eliminated No. 19 Emma Navarro 6-2, 6-1 in less than an hour.

Navarro got past four-time major champion Naomi Osaka and reigning U.S. Open champ Coco Gauff earlier in the tournament.

鈥淚 know this isn鈥檛 the last time I鈥檓 going to be in the quarterfinals of a Grand Slam,鈥 Navarro said. 鈥淚 know I鈥檒l be back.鈥

Vekic, a 28-year-old from Croatia, pondered quitting the sport on multiple occasions 鈥 including as recently as right before play began at Roland Garros in May.

鈥淚 didn鈥檛 have any energy, any motivation to keep practicing, keep pushing, because I felt like the last couple months I鈥檝e given everything for tennis, and I wasn鈥檛 getting the results that I kind of expected,鈥 Vekic said.

鈥淣ow I'm the semifinals,鈥 Vekic said. 鈥淣ot just in tennis, (but) in life, things can turn pretty fast.鈥

Sinner was a Wimbledon semifinalist a year ago and carried a nine-match winning streak into Tuesday, including a grass-court title at Halle, Germany, last month. He moved up to No. 1 in the ATP rankings, replacing there, on June 10 after getting to the semifinals at the French Open.

His exit follows that of the No. 1 women's seed, Iga Swiatek, in the third round. It is the first time since 2018 that both the top woman and top man are gone from Wimbledon before the semifinals. That year, Roger Federer lost in the quarterfinals, and Simona Halep in the third round.

Against Sinner in Australia, Medvedev took the first two sets. But Sinner clawed all the way back to win his first Grand Slam title.

That result dropped Medvedev鈥檚 career record in major finals to 1-5. Now he鈥檚 one victory from a seventh such appearance.

鈥淗opefully I can win some more Grand Slams,鈥 Medvedev said. 鈥淚 believe in myself. I believe in my tennis.鈥

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