WASHINGTON (AP) 鈥 For decades, proponents of psychedelic drugs have come to Washington with a provocative message: Illegal, mind-altering substances like LSD and ecstasy should be approved for Americans grappling with depression, trauma and other hard-to-treat conditions.
A presidential administration finally seems to agree.
鈥淭his line of therapeutics has tremendous advantage if given in a clinical setting and we are working very hard to make sure that happens within 12 months,鈥 Health recently told members of Congress.
His suggested timeline for green-lighting surprised even the most bullish supporters of the drugs. And it comes as in deep red states like Texas, where former Trump cabinet secretary and ex-governor has thrown his full support behind the effort.
The administration's has sparked both excitement as well as concern from those in the field, who worry the drugs might be discredited if they appear to be rushed onto the market or are too closely linked with Kennedy, who is known for controversial views on , antidepressants and .
鈥淚鈥檓 quite optimistic,鈥 says Rick Doblin, whose has pursued the medical use of MDMA (or ecstasy) since the 1980s. 鈥淏ut I鈥檓 also worried that the message the public might get is 鈥榃ell, RFK likes psychedelics and now it鈥檚 approved.鈥欌
FDA may reconsider MDMA
Under President Joe Biden, the as a treatment for post-traumatic stress disorder, citing . Regulators called for a new study, likely taking several years. It was a major setback for hoping to see the first U.S. approval of a psychedelic for medical use.
But the agency appears ready to reconsider. , who reports to Kennedy, has called the evaluation of MDMA and other psychedelics 鈥渁 top priority,鈥 announcing a slate of initiatives that could be used to accelerate their approval.
One new program promises to expedite drugs that serve 鈥渢he health interests of Americans,鈥 by slashing their review time from six months or more to as little as one month. Makary has also suggested greater flexibility on requirements for certain drugs, potentially waiving rigorous controlled studies that compare patients to a placebo group.
That approach, considered essential for high-quality research, has long been a stumbling point for psychedelic studies, in which patients can almost always correctly guess whether they鈥檝e received the drug or a dummy pill.
The U.S. Department of Health and Human Services and FDA also recently hired several new staffers with ties to the psychedelic movement.
鈥淭hese are all very promising signs that the administration is aware of the potential of psychedelics and is trying to make overtures that they鈥檙e ready to approve them,鈥 said Greg Ferenstein, a fellow at the libertarian Reason Foundation, who also consults for psychedelic companies. 鈥淲e didn鈥檛 hear anything about that in the Biden administration鈥
A spokesperson for HHS did not respond to a request for comment.
As a presidential candidate, Kennedy discussed how his son and several close friends benefited from using psychedelics to deal with grief and other issues.
A number of have already met with Trump's Secretary of Veterans Affairs, Doug Collins.
鈥淲hat we鈥檙e seeing so far is positive,鈥 Collins told House lawmakers in May.
But some experts worry the hope and hype surrounding psychedelics has gotten ahead of the science.
Philip Corlett, a psychiatric researcher at Yale University, says bypassing rigorous clinical trials could set back the field and jeopardize patients.
"If RFK and the new administration are serious about this work, there are things they could do to shepherd it into reality by meeting the benchmarks of medical science," Corlett said. 鈥淚 just don鈥檛 think that鈥檚 going to happen.鈥
Texas goes all-in on ibogaine research
As officials in Washington weigh the future of psychedelics, some states are moving ahead with their own projects in hopes of nudging the federal government. Oregon and have legalized .
And last month, Texas approved $50 million to study ibogaine, a potent psychedelic made from a shrub that's native to West Africa, as a treatment for opioid addiction, PTSD and other conditions. The research grant 鈥 the largest of its kind by any government 鈥 passed with support from the state's former GOP governor, Perry, and combat veterans, some who have traveled to clinics in Mexico that offer ibogaine.
Ibogaine is on the U.S. government鈥檚 ultra-restrictive list of illegal, Schedule 1 drugs, which also includes heroin. So advocates in Texas are hoping to build a national movement to ease restrictions on researching its use.
鈥淕overnmental systems move slowly and inefficiently,鈥 said Bryan Hubbard of Americans for Ibogaine, a group formed with Perry. 鈥淪ometimes you find yourself constrained in terms of the progress you can make from within.鈥
Ibogaine is unique among psychedelics in both its purported benefits and risks. Small studies and anecdotal reports suggest the drug may be able to dramatically ease addiction and trauma. It was sold for medical use in France for several decades starting in the 1930s, but the drug can also cause dangerous irregular heart rhythms, which can be fatal if left untreated.
Some veterans who have taken the drug say the risks can be managed and ibogaine鈥檚 healing properties go far beyond antidepressants, mood stabilizers, counseling and other standard treatments.
Marcus Capone struggled with anger, insomnia and mood swings after 13 years as a Navy Seal. In 2017, at the urging of his wife Amber, he agreed to try ibogaine as a last resort. He described his first ibogaine session as 鈥渁 complete purge of everything.鈥
鈥淏ut afterward I felt the weight just completely off my shoulders,鈥 he said. 鈥淣o more anxiety, no more depression, life made sense all of a sudden.鈥
A nonprofit founded by the Capones, Veterans Exploring Treatment Solutions, or VETS, has helped over 1,000 veterans travel abroad to receive ibogaine and other psychedelics.
But federal scientists have looked at the drug before 鈥 three decades ago, when the 好色tv Institute on Drug Abuse funded preliminary studies on using it as an addiction treatment. The research was discontinued after it identified 鈥渃ardiovascular toxicity."
鈥淚t would be dead in the water,鈥 in terms of winning FDA approval, longtime NIDA director Nora Volkow said.
But Volkow said her agency remains interested in psychedelics, including ibogaine, and is funding an American drugmaker that's working to develop a safer, synthetic version of the drug.
鈥淚 am very intrigued by their pharmacological properties and how they are influencing the brain,鈥 Volkow said. 鈥淏ut you also have to be very mindful not to fall into the hype and to be objective and rigorous in evaluating them.鈥
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute鈥檚 Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
