Rob Reiner, the son of a comedy giant who became one himself as one of the preeminent filmmakers of his generation with movies such as “The Princess Bride,†“When Harry Met Sally …†and “This Is Spinal Tap,†has died. He was 78.

Reiner and his wife, Michele Singer, were in the Brentwood neighborhood of Los Angeles. A law enforcement official briefed on the investigation confirmed their identities but could not publicly discuss details of the investigation and spoke to The Associated Press on condition of anonymity.

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