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Los Angeles Police had not identified a suspect, Deputy Chief Alan Hamilton, the chief of detectives, said at a briefing on Sunday night.

“We are going to try to speak to every family member that we can to get to the facts of this investigation,� Hamilton said.

The Los Angeles Fire Department said it responded to a medical aid request shortly after 3:30 p.m. and found a 78-year-old man and 68-year-old woman dead inside. Reiner turned 78 in March.

Detectives with the Robbery Homicide Division were investigating an “apparent homicide� at Reiner’s home, said Capt. Mike Bland with the Los Angeles Police Department.

Los Angeles authorities have not confirmed the identities of the people found dead at the residence in the upscale Brentwood neighborhood on the city’s west side that’s home to many celebrities.

Reiner was long one of the most prolific directors in Hollywood, and his work included some of the most memorable movies of the 1980s and ’90s, including “This is Spinal Tap,� “A Few Good Men,� “When Harry Met Sally� and “The Princess Bride.�

His role as Meathead in Norman Lear's 1970s TV classic “All in the Family,� as a liberal foil to O’Connor’s Archie Bunker, catapulted him to fame and won him two Emmy Awards.

Relatives of Lear, the , said the deaths left them bereft.

“Norman often referred to Rob as a son, and their close relationship was extraordinary, to us and the world,� said a Lear family statement. “Norman would have wanted to remind us that Rob and Michele spent every breath trying to make this country a better place, and they pursued that through their art, their activism, their philanthropy, and their love for family and friends.�

Messages to Reiner's representatives were not immediately returned Sunday night.

Los Angeles Mayor Karen Bass called it a devastating loss for the city.

“Rob Reiner’s contributions reverberate throughout American culture and society, and he has improved countless lives through his creative work and advocacy fighting for social and economic justice,� Bass said in a statement. “An acclaimed actor, director, producer, writer, and engaged political activist, he always used his gifts in service of others.�

The son of comedy legend Carl Reiner, Rob Reiner was married to photographer Michele Singer Reiner since 1989. The two met while he was directing “When Harry Met Sally� and have three children together.

Reiner was previously married to actor-director Penny Marshall from 1971 to 1981. He adopted her daughter, Tracy Reiner. at age 98 and .

Killings are rare in the Brentwood neighborhood. The scene is about a mile from the home where O.J. Simpson’s wife Nicole Brown Simpson and her friend Ron Goldman were killed in 1994.

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Balsamo reported from Washington. Associated Press Entertainment Writer Andrew Dalton in Los Angeles contributed.