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Picket lines formed outside major hospitals and hundreds of doctors marched past the prime minister's 10 Downing St. residence to Parliament, chanting “We are off to Australia� — in reference to doctors' higher wages abroad.

Junior doctors — those in the first years of their careers — make up almost half of all NHS doctors. Health service bosses say as many as 350,000 scheduled operations and appointments will be canceled during the walkout. Senior doctors and other medics have had to be drafted in to cover for emergency services, critical care and maternity services.

Stephen Powis, medical director of NHS England, said the walkout “is going to be the most disruptive period of strike action that we’ve seen this winter, probably the most disruptive period of action in NHS history.�

The British Medical Association, the doctors’ trade union, is seeking a 35% pay raise to make up for what it says are years of below-inflation increases. The union says newly qualified medics earn just 14.09 pounds ($17) an hour — the U.K. minimum wage is just over 10 pounds an hour — though salaries rise rapidly after the first year.

"Four of my close friends went to Australia and New Zealand to work and never came back," said Dr. Mike Andrews, standing on a picket line outside the Royal London Hospital. “I can’t leave because of my family but I am worried about how I am going to do my job in a week, a month, a year’s time when we can’t staff the wards already because they are leaving."

Dr. Vivek Trivedi, co-chairperson of the union's junior doctors committee, said the walkout could be stopped if Health Secretary Steve Barclay made a “credible offer� on pay. The government says it is willing to negotiate if the strike is called off, but calls the 35% demand unaffordable.

A wave of strikes has disrupted Britons’ lives for months, as workers demand pay raises to keep pace with soaring inflation, which stood at 10.4% in February.

Nurses, ambulance crews, teachers, border staff, driving examiners, bus drivers and postal workers have all walked off their jobs to demand higher pay.

Unions say wages, especially in the public sector, have fallen in real terms over the past decade, and a cost-of-living crisis fueled by sharply rising food and energy prices has left many struggling to pay their bills.