ROME (AP) — Wednesday's deadly shipwreck off southern Greece, involving a large boat carrying migrants that capsized after apparently rebuffing offers of help, is just the latest case of smugglers packing vessels full of desperate people willing to risk their lives to reach continental Europe.

The trip from Libya or Tunisia through the Central Mediterranean and north to Europe is the deadliest migratory route in the world, according to the U.N.’s International Organization of Migration.

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